You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Integrin-linked kinase regulates the niche of quiescent epidermal stem cells
|
|---|---|
| Published in |
Nature Communications, September 2015
|
| DOI | 10.1038/ncomms9198 |
| Pubmed ID | |
| Authors |
Jessica Morgner, Sushmita Ghatak, Tobias Jakobi, Christoph Dieterich, Monique Aumailley, Sara A. Wickström |
| Abstract |
Stem cells reside in specialized niches that are critical for their function. Quiescent hair follicle stem cells (HFSCs) are confined within the bulge niche, but how the molecular composition of the niche regulates stem cell behaviour is poorly understood. Here we show that integrin-linked kinase (ILK) is a key regulator of the bulge extracellular matrix microenvironment, thereby governing the activation and maintenance of HFSCs. ILK mediates deposition of inverse laminin (LN)-332 and LN-511 gradients within the basement membrane (BM) wrapping the hair follicles. The precise BM composition tunes activities of Wnt and transforming growth factor-β pathways and subsequently regulates HFSC activation. Notably, reconstituting an optimal LN microenvironment restores the altered signalling in ILK-deficient cells. Aberrant stem cell activation in ILK-deficient epidermis leads to increased replicative stress, predisposing the tissue to carcinogenesis. Overall, our findings uncover a critical role for the BM niche in regulating stem cell activation and thereby skin homeostasis. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 13% |
| United Kingdom | 2 | 13% |
| Finland | 1 | 7% |
| Korea, Republic of | 1 | 7% |
| Denmark | 1 | 7% |
| Unknown | 8 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 40% |
| Science communicators (journalists, bloggers, editors) | 4 | 27% |
| Scientists | 4 | 27% |
| Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 2% |
| United States | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 116 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 25% |
| Researcher | 27 | 23% |
| Student > Master | 16 | 13% |
| Student > Bachelor | 12 | 10% |
| Student > Postgraduate | 5 | 4% |
| Other | 11 | 9% |
| Unknown | 19 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 36% |
| Agricultural and Biological Sciences | 34 | 28% |
| Medicine and Dentistry | 11 | 9% |
| Engineering | 3 | 3% |
| Neuroscience | 2 | 2% |
| Other | 5 | 4% |
| Unknown | 22 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2020.
All research outputs
#2,683,772
of 22,826,360 outputs
Outputs from Nature Communications
#27,002
of 47,010 outputs
Outputs of similar age
#37,297
of 267,498 outputs
Outputs of similar age from Nature Communications
#385
of 764 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,010 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,498 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 764 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.