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Total Synthesis of the Norhasubanan Alkaloid Stephadiamine

Overview of attention for article published in Journal of the American Chemical Society, June 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

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Title
Total Synthesis of the Norhasubanan Alkaloid Stephadiamine
Published in
Journal of the American Chemical Society, June 2018
DOI 10.1021/jacs.8b01918
Pubmed ID
Authors

Nina Hartrampf, Nils Winter, Gabriele Pupo, Brian M. Stoltz, Dirk Trauner

Abstract

(+)-Stephadiamine is an unusual alkaloid isolated from the vine Stephania japonica. It features a norhasubanan skeleton, and contains two adjacent α-tertiary amines, which renders it an attractive synthetic target. Here, we present the first total synthesis of stephadiamine, which hinges on an efficient cascade reaction to implement the aza[4.3.3]propellane core of the alkaloid. The α--aminolactone moiety in a highly hindered position was installed via Tollens reaction and Curtius rearrangement. Useful building blocks for the asymmetric synthesis of morphine and (nor)hasubanan alka-loids are introduced.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 80 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 25%
Student > Master 14 18%
Researcher 11 14%
Student > Bachelor 6 8%
Student > Doctoral Student 5 6%
Other 9 11%
Unknown 15 19%
Readers by discipline Count As %
Chemistry 51 64%
Biochemistry, Genetics and Molecular Biology 3 4%
Engineering 2 3%
Agricultural and Biological Sciences 1 1%
Medicine and Dentistry 1 1%
Other 3 4%
Unknown 19 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2023.
All research outputs
#2,181,270
of 25,545,162 outputs
Outputs from Journal of the American Chemical Society
#4,815
of 66,867 outputs
Outputs of similar age
#44,091
of 341,842 outputs
Outputs of similar age from Journal of the American Chemical Society
#68
of 484 outputs
Altmetric has tracked 25,545,162 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 66,867 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,842 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 484 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.