Title |
Camelid and shark single domain antibodies: structural features and therapeutic potential
|
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Published in |
Current Opinion in Structural Biology, November 2016
|
DOI | 10.1016/j.sbi.2016.10.019 |
Pubmed ID | |
Authors |
Doreen Könning, Stefan Zielonka, Julius Grzeschik, Martin Empting, Bernhard Valldorf, Simon Krah, Christian Schröter, Carolin Sellmann, Björn Hock, Harald Kolmar |
Abstract |
In addition to canonical antibodies composed of heavy and light chains, the adaptive immune systems of camelids and cartilaginous fish comprise heavy-chain only isotypes (HcAb) devoid of light chains, where antigen-binding is mediated exclusively by one variable domain. Due to their inherent favorable attributes, such as high affinity and specificity for their cognate antigen, extraordinary stability, small size and, most importantly, the possibility to complement classical antibodies in terms of 'drugable' target-space, HcAb-derived entities evolved as promising candidates for biomedical applications of which many have already proven to be successful in early stage clinical trials. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Bangladesh | 1 | 33% |
United States | 1 | 33% |
Romania | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Spain | 1 | <1% |
Czechia | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 250 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 41 | 16% |
Researcher | 38 | 15% |
Student > Bachelor | 36 | 14% |
Student > Master | 26 | 10% |
Student > Doctoral Student | 10 | 4% |
Other | 31 | 12% |
Unknown | 72 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 74 | 29% |
Agricultural and Biological Sciences | 36 | 14% |
Immunology and Microbiology | 17 | 7% |
Chemistry | 10 | 4% |
Medicine and Dentistry | 8 | 3% |
Other | 29 | 11% |
Unknown | 80 | 31% |