Title |
Coiled Coils – A Model System for the 21st Century
|
---|---|
Published in |
Trends in Biochemical Sciences, November 2016
|
DOI | 10.1016/j.tibs.2016.10.007 |
Pubmed ID | |
Authors |
Andrei N. Lupas, Jens Bassler |
Abstract |
α-Helical coiled coils were described more than 60 years ago as simple, repetitive structures mediating oligomerization and mechanical stability. Over the past 20 years, however, they have emerged as one of the most diverse protein folds in nature, enabling many biological functions beyond mechanical rigidity, such as membrane fusion, signal transduction, and solute transport. Despite this great diversity, their structures can be described by parametric equations, making them uniquely suited for rational protein design. Far from having been exhausted as a source of structural insight and a basis for functional engineering, coiled coils are poised to become even more important for protein science in the coming decades. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Hong Kong | 1 | <1% |
Unknown | 242 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 61 | 25% |
Researcher | 43 | 18% |
Student > Master | 27 | 11% |
Student > Bachelor | 24 | 10% |
Student > Doctoral Student | 16 | 7% |
Other | 26 | 11% |
Unknown | 46 | 19% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 85 | 35% |
Agricultural and Biological Sciences | 40 | 16% |
Chemistry | 37 | 15% |
Physics and Astronomy | 6 | 2% |
Engineering | 6 | 2% |
Other | 20 | 8% |
Unknown | 49 | 20% |