Title |
A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.
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Published in |
Genome Research, April 1996
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DOI | 10.1101/gr.6.4.314 |
Pubmed ID | |
Authors |
M A Ansari-Lari, D M Muzny, J Lu, F Lu, C E Lilley, S Spanos, T Malley, R A Gibbs |
Abstract |
The genomic sequence of the human CD4 gene and its neighboring region, located at chromosome 12p13, was generated using the large-scale shotgun sequencing strategy. A total of 117 kb of genomic sequence and approximately 11 kb of cDNA sequence were obtained. Six genes, including CD4, triosephosphate isomerase, B3 subunit of G proteins (GNB3), and ubiquitin isopeptidase T (ISOT), with known functions, and two new genes with unknown functions were identified. Using a battery of strategies, the exon/intron boundaries, splice variants, and tissue expression patterns of the genes were determined. Various computer software was utilized for analyses of the DNA and amino acid sequences. The results of the analyses and sequence-based strategies for gene identification are discussed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Philippines | 1 | 3% |
Unknown | 36 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 24% |
Student > Bachelor | 6 | 16% |
Student > Postgraduate | 4 | 11% |
Lecturer | 3 | 8% |
Student > Master | 3 | 8% |
Other | 4 | 11% |
Unknown | 9 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 29% |
Medicine and Dentistry | 7 | 18% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Immunology and Microbiology | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 2 | 5% |
Unknown | 10 | 26% |